Research Project
Full description The research focuses on the colony-stimulating factor 1 receptor (CSF1R) crucial for the development and maintenance of macrophages. It highlights the discovery of a significant enhancer, the Fms intronic regulatory element (FIRE), within the Csf1r gene, necessary for CSF1R expression in specific macrophage populations across various tissues. This study relates specifically to the impact of microglial deficiency in FIRE knockout mice.