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Transcriptomic analysis of brain regions from wild type and Csf1r-FIRE mutant mice

The University of Queensland
Dr Katharine Irvine (Aggregated by) Honorary Professor Kim Summers (Aggregated by) Professor David Hume (Aggregated by)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=info:doi10.48610/e6f7777&rft.title=Transcriptomic analysis of brain regions from wild type and Csf1r-FIRE mutant mice&rft.identifier=RDM ID: 07e97ae2-a6d0-44e3-9e5c-a825c908c3fe&rft.publisher=The University of Queensland&rft.description=RNA-seq was used to define the transcriptomic profile of multiple brain regions of wild-type and microglia-deficient mice with a deletion of a regulatory element (FIRE) in the Csf1r locus . The data is contained within Excel spread sheets as follows: Table S1. Total RNA-seq analysis of multiple brain regions from WT and Fireko mice at 2 weeks of age. Table S2. Total RNA-seq analysis of multiple brain regions from WT and Fireko mice at 6 weeks of age. Table S3. Co-expression clusters identified by network analysis of combined RNA-seq data from multiple brain regions from WT and Fireko mice at 6 weeks of age. Table S4. Total RNA-seq analysis of thalamus from WT, Fireko, and Fireko + BMT mice at 30 weeks of age; 27 weeks post wild-type bone marrow transfer (BMT). Table S5. Total RNA-seq analysis of cortex from WT, Fireko, and Fireko + BMT mice at 30 weeks of age (27 weeks post BMT). Table S6. Differentially expressed gene (DEG) analysis comparing Fireko to WT, Fireko + BMT to WT, and Venn diagram comparing DEG list from this study to DEG list from Du et al (2026) Table S7. Co-expression clusters identified by network analysis of combined RNA-seq data from thalamus and cortex from WT, Fireko, and Fireko + BMT mice at 30 weeks of age (27 weeks post BMT).&rft.creator=Dr Katharine Irvine&rft.creator=Honorary Professor Kim Summers&rft.creator=Professor David Hume&rft.date=2026&rft_rights= https://guides.library.uq.edu.au/deposit-your-data/license-reuse-data-agreement&rft_subject=eng&rft_subject=CSF1R&rft_subject=brain transcriptome&rft_subject=thalamus&rft_subject=cerebral cortex&rft_subject=bone marrow transplantation&rft_subject=co-expression network&rft_subject=differentially expressed genes&rft_subject=Cell development, proliferation and death&rft_subject=Biochemistry and cell biology&rft_subject=BIOLOGICAL SCIENCES&rft_subject=Cellular immunology&rft_subject=Immunology&rft_subject=BIOMEDICAL AND CLINICAL SCIENCES&rft_subject=Innate immunity&rft.type=dataset&rft.language=English Access the data
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Faculty of Medicine

Full description

RNA-seq was used to define the transcriptomic profile of multiple brain regions of wild-type and microglia-deficient mice with a deletion of a regulatory element (FIRE) in the Csf1r locus . The data is contained within Excel spread sheets as follows: Table S1. Total RNA-seq analysis of multiple brain regions from WT and Fireko mice at 2 weeks of age. Table S2. Total RNA-seq analysis of multiple brain regions from WT and Fireko mice at 6 weeks of age. Table S3. Co-expression clusters identified by network analysis of combined RNA-seq data from multiple brain regions from WT and Fireko mice at 6 weeks of age. Table S4. Total RNA-seq analysis of thalamus from WT, Fireko, and Fireko + BMT mice at 30 weeks of age; 27 weeks post wild-type bone marrow transfer (BMT). Table S5. Total RNA-seq analysis of cortex from WT, Fireko, and Fireko + BMT mice at 30 weeks of age (27 weeks post BMT). Table S6. Differentially expressed gene (DEG) analysis comparing Fireko to WT, Fireko + BMT to WT, and Venn diagram comparing DEG list from this study to DEG list from Du et al (2026) Table S7. Co-expression clusters identified by network analysis of combined RNA-seq data from thalamus and cortex from WT, Fireko, and Fireko + BMT mice at 30 weeks of age (27 weeks post BMT).

Issued: 2026

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Subjects
Biological Sciences | Biomedical and Clinical Sciences | Biochemistry and Cell Biology | CSF1R | Cell Development, Proliferation and Death | Cellular Immunology | Immunology | Innate Immunity | bone marrow transplantation | brain transcriptome | cerebral cortex | co-expression network | differentially expressed genes | eng | thalamus |

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Identifiers
ACN 633 798 857