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Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of ​tetracycline

The University of Queensland
Dr Mark Davies (Aggregated by) Dr Mark Davies (Aggregated by)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=info:doi10.14264/uql.2016.581&rft.title=Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of ​tetracycline&rft.identifier=10.14264/uql.2016.581&rft.publisher=The University of Queensland&rft.description=We show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of ​tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.&rft.creator=Dr Mark Davies&rft.creator=Dr Mark Davies&rft.date=2014&rft_rights=2014, The University of Queensland&rft_rights= https://guides.library.uq.edu.au/deposit-your-data/license-reuse-data-agreement&rft_subject=eng&rft_subject=Biological sciences&rft_subject=Evolution&rft_subject=Genetics&rft_subject=Microbiology&rft_subject=Microbial Genetics&rft_subject=BIOLOGICAL SCIENCES&rft_subject=MICROBIOLOGY&rft_subject=GENETICS&rft.type=dataset&rft.language=English Access the data
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We show by comparative genome analysis and phylogenetic reconstruction of 229 isolates that the rise of human GBS infections corresponds to the selection and worldwide dissemination of only a few clones. The parallel expansion of the clones is preceded by the insertion of integrative and conjugative elements conferring tetracycline resistance (TcR). Thus, we propose that the use of ​tetracycline from 1948 onwards led in humans to the complete replacement of a diverse GBS population by only few TcR clones particularly well adapted to their host, causing the observed emergence of GBS diseases in neonates.

Issued: 2014

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Biological Sciences | Biological sciences | Evolution | Genetics | Genetics | Microbiology | Microbial Genetics | Microbiology | eng |

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Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline

local : UQ:336640

Da Cunha, Violette, Davies, Mark R., Douarre, Pierre-Emmanuel, Rosinski-Chupin, Isabelle, Margarit, Immaculada, Spinali, Sebastien, Perkins, Tim, Lechat, Pierre, Dmytruk, Nicolas, Sauvage, Elisabeth, Ma, Laurence, Romi, Benedetta, Tichit, Magali, Lopez-Sanchez, Maria-Jose, Descorps-Declere, Stephane, Souche, Erika, Buchrieser, Carmen, Trieu-Cuot, Patrick, Moszer, Ivan, Clermont, Dominique, Maione, Domenico, Bouchier, Christiane, McMillan, David J., Parkhill, Julian, Telford, John L., Dougan, Gordan, Walker, Mark J., The DEVANI Consortium, Holden, Matthew T. G. ... Glaser, Philippe (2014). Streptococcus agalactiae clones infecting humans were selected and fixed through the extensive use of tetracycline. Nature Communications, 5 (1) 4544, 4544.1-4544.11. doi: 10.1038/ncomms5544

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local : UQ:289097

School of Chemistry and Molecular Biosciences

local : UQ:3825

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