Research Project
Researchers: Professor Hamish Scott (Managed by)
Brief description MicroRNAs (miRNAs) are small non-coding RNAs that can exert multilevel inhibition/repression at a post-transcriptional or protein synthesis level during disease or development. Characterisation of miRNAs in adult mammalian brains by deep sequencing has been reported previously. However, to date, no small RNA profiling of the developing brain has been undertaken using this method. In this study, deep sequencing and small RNA analysis of a developing (E15.5) mouse brain was performed. This work was supported by National Health and Medical Research Council fellowships (171601 and 461204); National Health and Medical Research Council Grants 219176, 257501 and 257529.