Data

Transcriptomics of the Human Hypothalamus across the FTD-MND Spectrum

The University of Queensland
Associate Professor Frederik Steyn (Aggregated by) Associate Professor Shyuan Ngo (Aggregated by) Associate Professor Shyuan Ngo (Aggregated by) Dr Frederik Steyn (Aggregated by) Dr Quan Nguyen (Aggregated by)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=info:doi10.48610/1b78523&rft.title=Transcriptomics of the Human Hypothalamus across the FTD-MND Spectrum&rft.identifier=RDM ID: e449733e-df7a-4c58-9fd8-afa6860d2f44&rft.publisher=The University of Queensland&rft.description=This dataset contains raw count data, derivatives (as Seurat objects), and analysis result tables (supplementary tables for upcoming thesis and manuscripts) derived from single-nucleus RNA sequencing and spatial transcriptomics experiments. Tissues were collected from the Sydney Brain Bank and consist of hypothalamus tissues from donors on the frontotemporal dementia (FTD) and motor neuron disease (MND) spectrum. Single-nuclei (Chromium Flex for FFPE) data was derived from 3 donors with MND, 3 donors with behavioural-variant FTD (bvFTD), and 2 donors with FTD-MND. Spatial transcriptomics (Visium HD for FFPE) was conducted on two donors with bvFTD.This dataset contains: derivative data (Seurat objects in .rds format)raw single-nuclei counts from 10x Chromium (CellRanger v7.2.0 output)analysis result tables (.xlsx)segmented counts from Visium HD (SpaceRanger v4 output) The generation of this data is supported by a Royal Brisbane and Women’s Hospital Foundation (private donation), Motor Neurone Disease Research Australia (NTI MND Research Grant and Murray Geale Research Grant), and the Brain Foundation.&rft.creator=Associate Professor Frederik Steyn&rft.creator=Associate Professor Shyuan Ngo&rft.creator=Associate Professor Shyuan Ngo&rft.creator=Dr Frederik Steyn&rft.creator=Dr Quan Nguyen&rft.creator=Dr Quan Nguyen&rft.creator=Ms Jeryn Chang&rft.creator=Ms Jeryn Chang&rft.creator=Ms Jeryn Chang&rft.date=2025&rft_rights= https://guides.library.uq.edu.au/deposit-your-data/license-reuse-data-agreement&rft_subject=eng&rft_subject=Neurology and neuromuscular diseases&rft_subject=Neurosciences&rft_subject=BIOMEDICAL AND CLINICAL SCIENCES&rft_subject=Genomics and transcriptomics&rft_subject=Bioinformatics and computational biology&rft_subject=BIOLOGICAL SCIENCES&rft.type=dataset&rft.language=English Access the data
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[email protected]
School of Biomedical Sciences

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This dataset contains raw count data, derivatives (as Seurat objects), and analysis result tables (supplementary tables for upcoming thesis and manuscripts) derived from single-nucleus RNA sequencing and spatial transcriptomics experiments. Tissues were collected from the Sydney Brain Bank and consist of hypothalamus tissues from donors on the frontotemporal dementia (FTD) and motor neuron disease (MND) spectrum. Single-nuclei (Chromium Flex for FFPE) data was derived from 3 donors with MND, 3 donors with behavioural-variant FTD (bvFTD), and 2 donors with FTD-MND. Spatial transcriptomics (Visium HD for FFPE) was conducted on two donors with bvFTD.This dataset contains: derivative data (Seurat objects in .rds format)raw single-nuclei counts from 10x Chromium (CellRanger v7.2.0 output)analysis result tables (.xlsx)segmented counts from Visium HD (SpaceRanger v4 output) The generation of this data is supported by a Royal Brisbane and Women’s Hospital Foundation (private donation), Motor Neurone Disease Research Australia (NTI MND Research Grant and Murray Geale Research Grant), and the Brain Foundation.

Issued: 2025

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Subjects
Biological Sciences | Biomedical and Clinical Sciences | Bioinformatics and Computational Biology | Genomics and Transcriptomics | Neurology and Neuromuscular Diseases | Neurosciences | eng |

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