Theoretical Studies on the KcsA Potassium Channel and the L-type Calcium Channel [ 2002-01-01 - 2004-12-31 ]

Research Grant

Researchers: Dr S H Chung (Chief Investigator) ,  The Australian National University (Managed by)

Brief description Theoretical Studies on the KcsA Potassium Channel and the L-type Calcium Channel. All electrical activities in the brain are regulated by opening and closing of ion channels. Thus, understanding their mechanisms is a fundamental problem in biology. The project is aimed at developing a theoretical model of two important types of ion channels. Using a supercomputer, we will first deduce the shape of the microstructure formed by a protein wall. Then, using a computer simulation technique, we will construct a set of physical models of biological ion channels, which will correctly replicate experimental observations. Such a theory will link the structure and function of an ion channel through the fundamental principles of physics.

Funding Amount $231,000

Funding Scheme Discovery Projects

View this grant in the ARC Data Portal