Data

The No-Significant-Effect Concentration

Australian Institute of Marine Science
Australian Institute of Marine Science (AIMS)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=https://apps.aims.gov.au/metadata/view/a71bfe39-9c20-4792-b3bb-7dbdd8291472&rft.title=The No-Significant-Effect Concentration&rft.identifier=https://apps.aims.gov.au/metadata/view/a71bfe39-9c20-4792-b3bb-7dbdd8291472&rft.publisher=Australian Institute of Marine Science (AIMS)&rft.description=An alternative toxicity estimate to the no-effect concentration (NEC) has been developed - the no-significant-effect concentration (NSEC). The no-effect concentration (NEC) is the preferred threshold metric for single-species toxicity tests applied to derive safe concentration thresholds for contaminants in the environment for use in species sensitivity distributions, but is only suitable when concentration–response (C-R) data exhibit a threshold response.The no-significant-effect concentration (NSEC) is better suited to C-R data for which the response is a monotonically decreasing function of concentration and no threshold effects are evident. A flexible, three-parameter sigmoidal function is used to describe the C-R relationship and detail both Bayesian and frequentist approaches to estimation and inference for the NSEC.Maintenance and Update Frequency: asNeeded&rft.creator=Australian Institute of Marine Science (AIMS) &rft.date=2026&rft_rights=Creative Commons Attribution 3.0 Australia License http://creativecommons.org/licenses/by/3.0/au/&rft_rights=Use Limitation: All AIMS data, products and services are provided as is and AIMS does not warrant their fitness for a particular purpose or non-infringement. While AIMS has made every reasonable effort to ensure high quality of the data, products and services, to the extent permitted by law the data, products and services are provided without any warranties of any kind, either expressed or implied, including without limitation any implied warranties of title, merchantability, and fitness for a particular purpose or non-infringement. AIMS make no representation or warranty that the data, products and services are accurate, complete, reliable or current. To the extent permitted by law, AIMS exclude all liability to any person arising directly or indirectly from the use of the data, products and services.&rft_rights=Attribution: Format for citation of metadata sourced from Australian Institute of Marine Science (AIMS) in a list of reference is as follows: Australian Institute of Marine Science (AIMS). (2023). The No-Significant-Effect Concentration. https://apps.aims.gov.au/metadata/view/a71bfe39-9c20-4792-b3bb-7dbdd8291472, accessed[date-of-access].&rft_subject=oceans&rft.type=dataset&rft.language=English Access the data
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Creative Commons Attribution 3.0 Australia License
http://creativecommons.org/licenses/by/3.0/au/

Use Limitation: All AIMS data, products and services are provided "as is" and AIMS does not warrant their fitness for a particular purpose or non-infringement. While AIMS has made every reasonable effort to ensure high quality of the data, products and services, to the extent permitted by law the data, products and services are provided without any warranties of any kind, either expressed or implied, including without limitation any implied warranties of title, merchantability, and fitness for a particular purpose or non-infringement. AIMS make no representation or warranty that the data, products and services are accurate, complete, reliable or current. To the extent permitted by law, AIMS exclude all liability to any person arising directly or indirectly from the use of the data, products and services.

Attribution: Format for citation of metadata sourced from Australian Institute of Marine Science (AIMS) in a list of reference is as follows: "Australian Institute of Marine Science (AIMS). (2023). The No-Significant-Effect Concentration. https://apps.aims.gov.au/metadata/view/a71bfe39-9c20-4792-b3bb-7dbdd8291472, accessed[date-of-access]".

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An alternative toxicity estimate to the no-effect concentration (NEC) has been developed - the no-significant-effect concentration (NSEC). The no-effect concentration (NEC) is the preferred threshold metric for single-species toxicity tests applied to derive safe concentration thresholds for contaminants in the environment for use in species sensitivity distributions, but is only suitable when concentration–response (C-R) data exhibit a threshold response.


The no-significant-effect concentration (NSEC) is better suited to C-R data for which the response is a monotonically decreasing function of concentration and no threshold effects are evident. A flexible, three-parameter sigmoidal function is used to describe the C-R relationship and detail both Bayesian and frequentist approaches to estimation and inference for the NSEC.

Lineage

Maintenance and Update Frequency: asNeeded

Notes

Credit
Fox, D. University of Melboure & Environmetrics Australia
Credit
Fisher, R (AIMS)

Modified: 16 10 2026

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Other Information
GitHub Repository link: NSEC_ETandC

url : https://github.com/open-AIMS/NSEC_ETandC

Fisher, R. and Fox, D.R. (2023), Introducing the No-Significant-Effect Concentration. Environ Toxicol Chem. https://doi.org/10.1002/etc.5610

doi : https://doi.org/10.1002/etc.5610

Identifiers
  • global : a71bfe39-9c20-4792-b3bb-7dbdd8291472
ACN 633 798 857