The biological and pathological functions of TDP-43 [ 2010-02-11 - 2013-02-09 ]

Research Grant

Researchers: Dr Lars Ittner (Chief Investigator) ,  Jürgen Götz (Chief Investigator) ,  Professor Nikolas Haass (Chief Investigator) ,  Professor Nikolas Haass (Chief Investigator)

Brief description The biological and pathological functions of TDP-43. The social and economic burden of neurodegenerative such as MND is enormous. A key histopathological hallmark of this and many other related diseases are deposits of the protein TDP-43. Our research aims at understanding its largely unknown functions, for example by generating transgenic animal models. These will form the base for the development for a TDP-43-directed drug treatment. The national benefit of this research is manifold: by deciphering basic biological mechanisms, patenting new data, developing treatment strategies for un-curable and fatal disorders, and expanding links to Australian biotech and international pharmaceutical companies.

Funding Amount $480,000

Funding Scheme Discovery Projects

View this grant in the ARC Data Portal