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Quantified behavioural and lipidomic data in response to memory acquisition in mice

The University of Queensland
Dr Isaac Akefe (Aggregated by) Dr Isaac Akefe (Aggregated by) Dr Merja Joensuu (Aggregated by) Dr Merja Joensuu (Aggregated by) Professor Frederic Meunier (Aggregated by)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=info:doi10.48610/4a44503&rft.title=Quantified behavioural and lipidomic data in response to memory acquisition in mice&rft.identifier=10.48610/4a44503&rft.publisher=The University of Queensland&rft.description=Dataset corresponding to the manuscript DDHD2-STXBP1 interaction mediates long-term memory via the generation of saturated free fatty acids”. The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a crucial role in learning and memory, but the mechanisms through which neuronal activity affects the brain's lipid landscape remain largely unexplored. Saturated FFAs, particularly myristic acid (C14:0), strongly increase during neuronal stimulation and memory acquisition, suggesting the involvement of phospholipase A1 (PLA1) activity in synaptic plasticity. Here, we show that genetic ablation of the DDHD2 isoform of PLA1 in mice markedly reduced saturated FFAs across the brain and memory performance in reward-based learning and spatial memory models prior to the development of neuromuscular deficits. DDHD2 was shown to bind to the key synaptic protein STXBP1. Using STXBP1/2 knockout neurosecretory cells and a haploinsufficient STXBP1+/- mouse model of STXBP1 encephalopathy that is also associated with intellectual disability and motor dysfunction, we show that STXBP1 controls the targeting of DDHD2 to the plasma membrane and the generation of saturated FFAs in the brain. Our findings suggest key roles for DDHD2 and STXBP1 in the lipid metabolism underlying synaptic plasticity, learning and memory.&rft.creator=Dr Isaac Akefe&rft.creator=Dr Isaac Akefe&rft.creator=Dr Merja Joensuu&rft.creator=Dr Merja Joensuu&rft.creator=Professor Frederic Meunier&rft.creator=Professor Frederic Meunier&rft.date=2023&rft.coverage=153.006732,-27.493663&rft_rights=2023, The University of Queensland&rft_rights= https://guides.library.uq.edu.au/deposit-your-data/license-reuse-data-agreement&rft_subject=eng&rft_subject=Lipids, Phospholipase A1; Free Fatty Acids; Myristic Acid; Learning and Memory&rft_subject=NEUROSCIENCES&rft_subject=MEDICAL AND HEALTH SCIENCES&rft.type=dataset&rft.language=English Access the data
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f.meunier@uq.edu.au

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Dataset corresponding to the manuscript "DDHD2-STXBP1 interaction mediates long-term memory via the generation of saturated free fatty acids”. The phospholipid and free fatty acid (FFA) composition of neuronal membranes plays a crucial role in learning and memory, but the mechanisms through which neuronal activity affects the brain's lipid landscape remain largely unexplored. Saturated FFAs, particularly myristic acid (C14:0), strongly increase during neuronal stimulation and memory acquisition, suggesting the involvement of phospholipase A1 (PLA1) activity in synaptic plasticity. Here, we show that genetic ablation of the DDHD2 isoform of PLA1 in mice markedly reduced saturated FFAs across the brain and memory performance in reward-based learning and spatial memory models prior to the development of neuromuscular deficits. DDHD2 was shown to bind to the key synaptic protein STXBP1. Using STXBP1/2 knockout neurosecretory cells and a haploinsufficient STXBP1+/- mouse model of STXBP1 encephalopathy that is also associated with intellectual disability and motor dysfunction, we show that STXBP1 controls the targeting of DDHD2 to the plasma membrane and the generation of saturated FFAs in the brain. Our findings suggest key roles for DDHD2 and STXBP1 in the lipid metabolism underlying synaptic plasticity, learning and memory.

Issued: 04 12 2023

Data time period: 04 2019 to 04 12 2023

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153.00673,-27.49366

153.006732,-27.493663

Subjects
Lipids, Phospholipase A1; Free Fatty Acids; Myristic Acid; Learning and Memory | Medical and Health Sciences | Neurosciences | eng |

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Identifying key changes in brain free fatty acids associated with memory in health, ageing and disease: A mechanistic study

local : UQ:a5c754a

Akefe, Isaac (2022). Identifying key changes in brain free fatty acids associated with memory in health, ageing and disease: A mechanistic study. PhD Thesis, Queensland Brain Institute, The University of Queensland. doi: 10.14264/a5c754a

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local : UQ:289097

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