Research Project
Full description Well characterised average models of morphological structure are critical to our understanding of systems biology. It is only by understanding the norms and variance of a structure that we can then identify abnormal structures that are, in general, related to functional change. In the area of brain research, this is fundamental to the understanding of the differences between individuals. As in the case of neuronal tissue, there is very often a strong link between a structural change and the way the organ functions. It is for this reason that average models of cortical anatomy for the most common animal models (mouse, rat, zebrafish) have been developed and published at various resolutions. This collection represents the current world best model of c57bl/6j mouse anatomy (the most commonly used mouse model) and wildtype zebrafish data. This in-vivo MRI data has then been combined with ex-vivo optical imaging to produce a comprehensive model of tissue function and structure. Multiple sub-regions of this data have been annotated by George Paxinos and Charles Watson, the authors of the most widely used and indeed canonical reference atlas of mouse anatomy. All data that will be included has been published in peer reviewed international journals and details of each publication as it relates to different parts of the model are detailed here: http://www.imaging.org.au/AMBMC Details of the original grants are also on this page and will be updated as new grants are gained for the continued collection of data.