Research Project
Full description SNARE-mediated secretory vesicle (SV) exocytosis underpins neuronal communication. Munc18-1 orchestrates SNARE complex formation by controlling the opening of syntaxin-1A. How the SV-plasma membrane interface becomes fusion competent at nanoscale level is unknown. Here, we propose that the interaction of Munc18-1 with VAMP2 during vesicular docking triggers nanocluster re-organization which renders the SV-plasma membrane interface fusion-competent