Data

Microbial Genomics Raw Sequence and Analysis Data

The University of Queensland
Associate Professor Scott Beatson (Aggregated by) Associate Professor Scott Beatson (Aggregated by) Mr Mitchell Stanton-Cook (Aggregated by)
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2015, The University of Queensland

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scott.beatson@uq.edu.au

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We aim to better understand the molecular mechanisms of infectious disease and identify potential therapeutic and diagnostic targets by exploiting next-generation genomic data. A major focus is the comparative analysis of genomes obtained from local clinical isolates (Brisbane & Australia) of important human pathogens such as Escherichia coli, Pseudomonas aeruginosa, Staphylococci, Streptococci, Legionella pneumophila and Acinetobacter baumannii. In particular we are interested in the evolution and mobility of genes encoding virulence factors that are widely conserved amongst bacterial pathogens (e.g., fimbriae, pili and type III and type IV secretion systems and secreted effectors). We have sequenced almost 1,000 bacterial genomes using a variety of different next-generation sequencing technologies (Illumina, SOLiD, 454, PacBio). This collection varies from just sequencing reads right through to annotated complete genomes that we have derived from the data.

Issued: 2015

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Subjects
Biochemistry and Cell Biology | Biological Sciences | Bioinformatics | Genetics | Genomics | Infectious disease | Microbes | Pathogens | eng |

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Other Information
Differential regulation of the surface-exposed and secreted SslE lipoprotein in extraintestinal pathogenic Escherichia coli

local : UQ:406767

Tan, Lendl, Moriel, Danilo G., Totsika, Makrina, Beatson, Scott A. and Schembri, Mark A. (2016). Differential regulation of the surface-exposed and secreted SslE lipoprotein in extraintestinal pathogenic Escherichia coli. PLoS One, 11 (9) e0162391, e0162391. doi: 10.1371/journal.pone.0162391

Comparative genomics of the Staphylococcus intermedius group of animal pathogens

local : UQ:284686

Ben Zakour, Nouri L., Beatson, Scott A., van den Broek, Adri H. M., Thoday, Keith L. and Fitzgerald, J. Ross (2012). Comparative genomics of the Staphylococcus intermedius group of animal pathogens. Frontiers in Cellular and Infection Microbiology, 2 ARTN 44, 44.1-44.15. doi: 10.3389/fcimb.2012.00044

A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug resistant uropathogenic Escherichia coli ST131

local : UQ:303306

Totsika, Makrina, Kostakioti, Maria, Hannan, Thomas J., Upton, Mathew, Beatson, Scott A., Janetka, James W., Hultgren, Scott J. and Schembri, Mark A. (2013). A FimH inhibitor prevents acute bladder infection and treats chronic cystitis caused by multidrug resistant uropathogenic Escherichia coli ST131. Journal of Infectious Diseases, 208 (6), 921-928. doi: 10.1093/infdis/jit245

Research Data Collections

local : UQ:289097

School of Chemistry and Molecular Biosciences

local : UQ:3825

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