Research Grant
[Cite as https://purl.org/au-research/grants/arc/LE260100005]
Researchers:
Alyson Ashe
(Chief Investigator)
,
Christopher McDevitt
(Chief Investigator)
,
Danny Hatters
(Chief Investigator)
,
Donna Whelan
(Chief Investigator)
,
Dr Lee H Wong
(Chief Investigator)
View all 13 related researchers
Brief description A next generation single-photon microscope for dynamic live cell biology. This project aims to establish a single-photon counting image scanning microscope that is capable of single-molecule fluorescence spectroscopy and empowers researchers across Australia to perform dynamic structural biology with unprecedented spatiotemporal resolution. By combining time-resolved single-photon counting electronics with single-photon avalanche diode array technology, this microscope will provide picosecond-level detection of fluorescent protein properties (intensity, lifetime, anisotropy) that can reveal nanoscale changes in protein structure down to the nanosecond timescale. This breakthrough is expected to advance Australian research by enabling direct observation of protein dynamics previously beyond reach in a living cell.
Funding Amount $1,025,000
Funding Scheme Linkage Infrastructure, Equipment and Facilities
- PURL : https://purl.org/au-research/grants/arc/LE260100005
- ARC : LE260100005