Isolation and analysis of novel caspases. [ 2003-01-07 - 2005-12-31 ]

Research Grant

Researchers: Dr Christine Hawkins (Chief Investigator) ,  Dr Paul Ekert (Chief Investigator)

Brief description Isolation and analysis of novel caspases. Apoptosis is an evolutionarily conserved cellular process which must be tightly controlled for normal development and to avoid disease. Rapid progress has been made recently in the elucidation of apoptotic pathways, but many important components are likely still unknown. The caspases constitute the effector arm of apoptotic signalling pathways and some members play important roles in cytokine maturation. We aim to identify novel caspases using an innovative technique, and to characterise their function and regulation. Molecules identified in this project may be candidate targets for therapies which modulate apoptosis for treatment or prevention of disease, or diagnostic reagent development.

Funding Amount $195,000

Funding Scheme Discovery Projects

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