Identification and characterisation of caspase inhibitors. [ 2005-01-01 - 2005-12-31 ]

Research Grant

Researchers: Dr Christine Hawkins (Chief Investigator) ,  Dr David Michael Ashley (Chief Investigator)

Brief description Identification and characterisation of caspase inhibitors. Organisms use a tightly controlled process of cell death (termed apoptosis) to remove dangerous and unwanted cells. Dysregulation of this process can contribute to diseases such as cancer and autoimmune disease. Caspases are protease effectors of apoptosis. Regulation of their activity is vital for effective control of cell survival and death. Using a functional screening system invented by the 1st CI, we aim to isolate and characterise novel inhibitors of caspases. Such inhibitors may in time be used as targets for development of therapeutic or diagnostic reagents aimed at manipulating the apoptotic process to diagnose, prevent or treat disease.

Funding Amount $156,000

Funding Scheme Discovery Projects

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