Data

Human bone marrow-derived stromal cell behaviour after pre-conditioned sub-lethal irradiation

Queensland University of Technology
Doran, Michael ; Williams , Elizabeth ; Futrega, Katarzyna
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=info:doi10.25912/RDF_1636694337751&rft.title=Human bone marrow-derived stromal cell behaviour after pre-conditioned sub-lethal irradiation&rft.identifier=10.25912/RDF_1636694337751&rft.publisher=Queensland University of Technology&rft.description=Direct bone marrow injection of cells into murine marrow cavities is used in a range of cell characterization assays and to develop disease models. While human bone marrow-derived stromal cells (hBMSC, also known as mesenchymal stem cells (MSC)) are frequently described in therapeutic applications, or disease modeling, their behavior following direct injection into murine bone marrow is poorly characterized. Herein, we characterized hBMSC engraftment and persistence within the bone marrow of NOD-scid interleukin (IL)-2γ-/- (NSG) mice with or without prior 2 Gy total-body γ-irradiation of recipient mice. &rft.creator=Doran, Michael &rft.creator=Williams , Elizabeth &rft.creator=Futrega, Katarzyna &rft.date=2021&rft.edition=1&rft.relation=https://eprints.qut.edu.au/209604/&rft.coverage=All data was collected in Brisbane, Queensland at either the Translational Research Institute or the Institute of Health and Biomedical Innovation. &rft_rights=© Queensland University of Technology, 2021. &rft_rights=Creative Commons Attribution 3.0 http://creativecommons.org/licenses/by/4.0/&rft_subject=Haemopoietic stem cells&rft_subject=Mesenchymal stromal cell&rft_subject=Fibroblasts&rft_subject=Mesenchymal stem cell&rft_subject=Bone marrow stromal cells&rft_subject=Bone marrow-derived stromal cells&rft_subject=Xenograft mouse models&rft.type=dataset&rft.language=English Access the data

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Creative Commons Attribution 3.0
http://creativecommons.org/licenses/by/4.0/

© Queensland University of Technology, 2021.

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Contact Information

Postal Address:
Associate Professor Michael Doran
Ph: +61 7 3443 7348

michael.doran@qut.edu.au

Full description

Direct bone marrow injection of cells into murine marrow cavities is used in a range of cell characterization assays and to develop disease models. While human bone marrow-derived stromal cells (hBMSC, also known as mesenchymal stem cells (MSC)) are frequently described in therapeutic applications, or disease modeling, their behavior following direct injection into murine bone marrow is poorly characterized. Herein, we characterized hBMSC engraftment and persistence within the bone marrow of NOD-scid interleukin (IL)-2γ-/- (NSG) mice with or without prior 2 Gy total-body γ-irradiation of recipient mice.

Data time period: 11 01 2016 to 11 04 2021

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Spatial Coverage And Location

text: All data was collected in Brisbane, Queensland at either the Translational Research Institute or the Institute of Health and Biomedical Innovation.

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