Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP0210675]Researchers: Prof Peter Reeves (Chief Investigator)
Brief description Genetics and evolution of Shigella O antigens. We use genome scale sequencing techniques to sequence 26 O-antigen gene clusters from Shigella. With the seven already known, this will give sequences for every O-antigen of Shigella. This will be the first time that such set is fully sequenced. Shigella are human specific pathogens, have emerged with the evolution of humans. O-antigens are important for their life and pathogenicity. This project will greatly extend our knowledge of the genetic basis and evolution of this important polymorphism. O-antigens are used for typing Shigella and also elicit strong immunity. The molecular data will help establish DNA based typing and vaccine development.
Funding Amount $176,000
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP0210675
- ARC : DP0210675