Research Project
Full description The GenDiP Consortium conducted trans-generational, multi-ancestry GWAS meta-analyses of gestational diabetes mellitus (GDM) and pregnancy glycemic traits in up to 30 cohorts of European (EUR), East Asian (EAS), South Asian (SAS), African-admixed (AFR), and Hispanic-admixed (HIS) ancestry. We analysed maternal (GDM: 38,305 cases, 776,145 controls; FG n = 55,371; 1hG n = 38,439; 2hG n = 46,401; HbA1c n = 9,724) and fetal (GDM: 3,126 cases, 90,877 controls; FG n = 15,855; 1hG n = 9,365; 2hG n = 15,046; HbA1c n = 7,035) genetic associations. Ancestry-specific analyses applied fixed-effect inverse-variance meta-analysis in METAL, while trans-ancestry analyses used MR-MEGA to account for heterogeneity. Fetal effects independent of maternal genotype were estimated with DINGO. To detect masked associations, mBAT-combo was applied to EUR and EAS summary statistics. The shared and distinct genetic architecture of GDM and type 2 diabetes (T2DM) was examined using genetic correlation, SCOUTJOY, shared variant analysis, and GWAS-by-subtraction (EUR only) to identify pregnancy-specific effects.