Dataset

fMRI correlates of stop-signal response inhibition in schizophrenia

Swinburne University of Technology
Matthew Hughes (Principal investigator)
Viewed: [[ro.stat.viewed]] Cited: [[ro.stat.cited]] Accessed: [[ro.stat.accessed]]
ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft.title=fMRI correlates of stop-signal response inhibition in schizophrenia&rft.identifier=swin-red: e01fdfb9a89af052cdc94a90c8ba1266&rft.publisher=Swinburne University of Technology&rft.description=Inhibitory control deficits are well documented in schizophrenia, supported by impairment in an established measure of response inhibition, the stop-signal reaction time (SSRT). We investigated the neural basis of this impairment by comparing schizophrenia patients and controls matched for age, sex and education on behavioural, functional magnetic resonance imaging (fMRI) and event-related potential (ERP) indices of stop-signal task performance. Compared to controls, patients exhibited slower SSRT and reduced right inferior frontal gyrus (rIFG) activation, but rIFG activation correlated with SSRT in both groups. Go stimulus and stop-signal ERP components (N1/P3) were smaller in patients, but the peak latencies of stop-signal N1 and P3 were also delayed in patients, indicating impairment early in stop-signal processing. Additionally, response-locked lateralised readiness potentials indicated response preparation was prolonged in patients. An inability to engage rIFG may predicate slowed inhibition in patients, however multiple spatiotemporal irregularities in the networks underpinning stop-signal task performance may contribute to this deficit. Data Extent/Access: Technical metadata descriptions are contained in the related publication. 20 GB data comprising 20 data sets each of 1Gb each in Analyze format. Related Publications: Hughes et al. (2012) Stop-signal response inhibition in schizophrenia: Behavioural, event-related potential and functional neuroimaging data http://hdl.handle.net/1959.3/208461&rft.creator=Matthew Hughes&rft.date=2013&rft_rights=Metadata/Data may be available upon request&rft_subject=170100&rft_subject=110900&rft_subject=schizophrenia&rft_subject=response inhibition&rft_subject=fMRI&rft.type=dataset&rft.language=English Access the data

Please use the contact information below to request access to this data.

Contact Information

Street Address:
Swinburne University of Technology



Licence & Rights:

view details

Metadata/Data may be available upon request

Access:

Other

Brief description

Inhibitory control deficits are well documented in schizophrenia, supported by impairment in an established measure of response inhibition, the stop-signal reaction time (SSRT). We investigated the neural basis of this impairment by comparing schizophrenia patients and controls matched for age, sex and education on behavioural, functional magnetic resonance imaging (fMRI) and event-related potential (ERP) indices of stop-signal task performance.

Compared to controls, patients exhibited slower SSRT and reduced right inferior frontal gyrus (rIFG) activation, but rIFG activation correlated with SSRT in both groups. Go stimulus and stop-signal ERP components (N1/P3) were smaller in patients, but the peak latencies of stop-signal N1 and P3 were also delayed in patients, indicating impairment early in stop-signal processing. Additionally, response-locked lateralised readiness potentials indicated response preparation was prolonged in patients. An inability to engage rIFG may predicate slowed inhibition in patients, however multiple spatiotemporal irregularities in the networks underpinning stop-signal task performance may contribute to this deficit.

Data Extent/Access:

  • Technical metadata descriptions are contained in the related publication.
  • 20 GB data comprising 20 data sets each of 1Gb each in Analyze format.

Related Publications:

Hughes et al. (2012) "Stop-signal response inhibition in schizophrenia: Behavioural, event-related potential and functional neuroimaging data" http://hdl.handle.net/1959.3/208461

Click to explore relationships graph
Subjects

User Contributed Tags    

Login to tag this record with meaningful keywords to make it easier to discover

Identifiers
  • Local : swin-red: e01fdfb9a89af052cdc94a90c8ba1266