Research Project
Full description Copper resistance is a key virulence trait of the uropathogen Proteus mirabilis. The suppressor of copper sensitivity protein C (PmScsC) contributes to this trait and has disulfide isomerase activity. This project showed that the disulfide isomerase activity of PmScsC is activated by PmScsBα. The crystal structure of PmScsBα was also solved and a small-angle neutron scattering derived model of the PmScsC-PmScsBα complex was generated.