Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP230102278]Researchers: Professor Frederic Meunier (Chief Investigator) , Professor Frederic Meunier (Chief Investigator) , George Augustine (Partner Investigator)
Brief description Role of Tau and Synapsin in clustering distinct synaptic vesicle pools. Neurotransmitter-containing synaptic vesicles (SVs) are highly enriched in specific locations of brain cells, called nerve terminals via an unknown mechanism. The clustering of SVs depend on the phosphorylation of an unknown set of proteins. Two key proteins have been identified for their phosphorylation pattern and their potential to form membraneless compartments: tau and synapsin. Using highly innovative single-molecule super-resolution microscopy, this grant will uncover how tau and synapsin phosphorylation controls the clustering of SVs thereby regulating neurotransmitter release. This project uses improved nanoscopic technologies and international\ncollaborations to unveil novel avenues in our understanding of brain communication.
Funding Amount $478,045
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP230102278
- ARC : DP230102278