Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP230101712]Researchers: Andrew J. Christofferson (Chief Investigator) , Prof Calum Drummond (Chief Investigator) , Tamar Greaves (Chief Investigator) , ARC Linkage Grant LP1701000985 (Funded by) , Jorge Fernando Brandão Pereira (Partner Investigator)
Brief description Improving the stability of biomolecules using ionic liquids. This project aims to address critical issues in studying proteins outside their native environments by developing new solvents that will increase their stability and solubility. The project expects to create new knowledge in our understanding of solvent chemical properties through a novel approach using high throughput robotics, synchrotron analysis of protein structures and Molecular Dynamics simulations. The expected outcome is a set of design rules for creating new solvents. This should benefit many research and industrial applications, including determining protein structure for the development of new drugs and biocatalysts, and cryopreservation of protein-based pharmaceuticals.
Funding Amount $439,000
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP230101712
- ARC : DP230101712