Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP160103559]Researchers: Dr Allan McRae (Chief Investigator) , Dr Allan McRae (Chief Investigator) , Neil Youngson (Chief Investigator) , Prof Margaret Morris (Chief Investigator) , ARC Linkage Grant LP1701000985 (Funded by)
Brief description The importance of DNA methylation in response to environmental changes. This project aims to investigate the importance of DNA methylation, a process whereby gene expression can be altered without changes in the DNA code, in regulating our responses to environmental challenges. It plans to do so using well-validated models of adult exposure to high fat diet or psychological stress in mice and tissue-specific (liver and brain) deletion of the major methylation enzymes. It aims to compare functional, gene expression and methylation status after such challenges in intact and methylase deleted animals to determine how vital this process really is. This work has major implications for our understanding of epigenetics, and the ways in which genes interact with the environment especially in times of change.
Funding Amount $364,600
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP160103559
- ARC : DP160103559