Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP150104515]Researchers: Christopher McDevitt (Chief Investigator) , Prof James Paton (Chief Investigator)
Brief description Bacterial poly-histidine triad proteins. The poly-histidine triad (Pht) proteins are a poorly characterised family of surface proteins expressed by the genus Streptococcus and other Gram-positive genera. Recent studies suggest an important role for Pht proteins in survival of these bacteria in low zinc (Zn) environments. The project hypothesis is that Pht proteins specifically recruit Zn from the extracellular environment and somehow make it available to ATP binding cassette (ABC) transport systems located in the bacterial plasma membrane, beneath the cell wall, facilitating Zn uptake by the bacterium. The aim of this project is to conduct comprehensive molecular characterization of the interactions between Pht proteins, Zn and ABC transporters, and the role of the histidine triad motifs in these interactions.
Funding Amount $384,300
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP150104515
- ARC : DP150104515