[Cite as http://purl.org/au-research/grants/arc/DP150104515]
Researchers Prof James Paton; Dr Christopher McDevitt
Brief description The poly-histidine triad (Pht) proteins are a poorly characterized family of surface proteins expressed by the genus Streptococcus and other Gram-positive genera. Our recent studies suggest an important role for Pht proteins in survival of these bacteria in low zinc environments. We hypothesise that Pht proteins specifically recruit Zn from the extracellular environment and somehow make it available to ABC transport systems located in the bacterial plasma membrane, beneath the cell wall, facilitating Zn uptake by the bacterium. This project will involve comprehensive molecular characterization of the interactions between Pht proteins, Zn and ABC transporters, and the role of the histidine triad motifs in these interactions.
Funding Amount 384300
Funding Scheme Discovery Projects