Full description
Phenotypes analysed: 1-hour glucose post-OGTT (1h_Glucose), 2-hour glucose post-OGTT (2h_Glucose), fasting glucose (FG), gestational diabetes mellitus (GDM), and glycated haemoglobin (HbA1c). DINGO analyses were performed in European ancestry samples. Maternal EUR analyses included FG (n = 17,810), 1hG (n = 7,736), 2hG (n = 10,784), HbA1c (n = 5,377), and GDM (n = 766,250; 29,640 cases). Fetal EUR analyses included FG (n = 6,629), 1hG (n = 4,465), 2hG (n = 5,838), HbA1c (n = 3,068), and GDM (n = 84,089; 1,484 cases). GDM genetic effects were transformed to the liability scale using the Wu et al. linear approximation. Output columns are: CHR (chromosome), SNP (rsID), BP (base-pair position b38), EA_F (effect allele for fetal effect), NEA (non-effect allele), BETA_F_ADJ (beta of conditional fetal effect), SE_F_ADJ (standard error of conditional fetal effect), P_F_ADJ (p-value of conditional fetal effect), BETA_M_ADJ (beta of conditional maternal effect), SE_M_ADJ (standard error of conditional maternal effect), P_M_ADJ (p-value of conditional maternal effect), P_2DF (p-value of the two degree-of-freedom test), P_F_META (p-value of fetal 1-df meta-analysis), and P_M_META (p-value of maternal 1-df meta-analysis). For further details on sample sizes, analytical pipelines, and cohort-specific QC procedures, see Supplementary Materials.Issued: 2025
Subjects
Biological Sciences |
Biomedical and Clinical Sciences |
Bioinformatics and Computational Biology |
Clinical Sciences |
Endocrinology |
Genetics |
Genomics |
Genomics and Transcriptomics |
Obstetrics and Gynaecology |
Reproductive Medicine |
Statistical and Quantitative Genetics |
eng |
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Other Information
Research Data Collections
local : UQ:289097
Identifiers
- Local : RDM ID: c5049a0f-bd9e-4ae7-8986-b087bc649809
- DOI : 10.48610/ED470A2