Data

DINGO summary statistics from "Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects"

The University of Queensland
Dr Gunn-Helen Moen (Aggregated by) Dr Gunn-Helen Moen (Aggregated by) Professor David Evans (Aggregated by) Professor David Evans (Aggregated by)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=info:doi10.48610/ed470a2&rft.title=DINGO summary statistics from Multi-ancestry, trans-generational GWAS meta-analysis of gestational diabetes and glycaemic traits during pregnancy reveals limited evidence of pregnancy-specific genetic effects&rft.identifier=RDM ID: c5049a0f-bd9e-4ae7-8986-b087bc649809&rft.publisher=The University of Queensland&rft.description=Phenotypes analysed: 1-hour glucose post-OGTT (1h_Glucose), 2-hour glucose post-OGTT (2h_Glucose), fasting glucose (FG), gestational diabetes mellitus (GDM), and glycated haemoglobin (HbA1c). DINGO analyses were performed in European ancestry samples. Maternal EUR analyses included FG (n = 17,810), 1hG (n = 7,736), 2hG (n = 10,784), HbA1c (n = 5,377), and GDM (n = 766,250; 29,640 cases). Fetal EUR analyses included FG (n = 6,629), 1hG (n = 4,465), 2hG (n = 5,838), HbA1c (n = 3,068), and GDM (n = 84,089; 1,484 cases). GDM genetic effects were transformed to the liability scale using the Wu et al. linear approximation. Output columns are: CHR (chromosome), SNP (rsID), BP (base-pair position b38), EA_F (effect allele for fetal effect), NEA (non-effect allele), BETA_F_ADJ (beta of conditional fetal effect), SE_F_ADJ (standard error of conditional fetal effect), P_F_ADJ (p-value of conditional fetal effect), BETA_M_ADJ (beta of conditional maternal effect), SE_M_ADJ (standard error of conditional maternal effect), P_M_ADJ (p-value of conditional maternal effect), P_2DF (p-value of the two degree-of-freedom test), P_F_META (p-value of fetal 1-df meta-analysis), and P_M_META (p-value of maternal 1-df meta-analysis). For further details on sample sizes, analytical pipelines, and cohort-specific QC procedures, see Supplementary Materials.&rft.creator=Dr Gunn-Helen Moen&rft.creator=Dr Gunn-Helen Moen&rft.creator=Professor David Evans&rft.creator=Professor David Evans&rft.date=2025&rft_rights= https://guides.library.uq.edu.au/deposit-your-data/license-reuse-data-agreement&rft_subject=eng&rft_subject=Genomics and transcriptomics&rft_subject=Bioinformatics and computational biology&rft_subject=BIOLOGICAL SCIENCES&rft_subject=Statistical and quantitative genetics&rft_subject=Genomics&rft_subject=Genetics&rft_subject=Endocrinology&rft_subject=Clinical sciences&rft_subject=BIOMEDICAL AND CLINICAL SCIENCES&rft_subject=Obstetrics and gynaecology&rft_subject=Reproductive medicine&rft.type=dataset&rft.language=English Access the data

Contact Information

[email protected]
Institute for Molecular Bioscience

Full description

Phenotypes analysed: 1-hour glucose post-OGTT (1h_Glucose), 2-hour glucose post-OGTT (2h_Glucose), fasting glucose (FG), gestational diabetes mellitus (GDM), and glycated haemoglobin (HbA1c). DINGO analyses were performed in European ancestry samples. Maternal EUR analyses included FG (n = 17,810), 1hG (n = 7,736), 2hG (n = 10,784), HbA1c (n = 5,377), and GDM (n = 766,250; 29,640 cases). Fetal EUR analyses included FG (n = 6,629), 1hG (n = 4,465), 2hG (n = 5,838), HbA1c (n = 3,068), and GDM (n = 84,089; 1,484 cases). GDM genetic effects were transformed to the liability scale using the Wu et al. linear approximation. Output columns are: CHR (chromosome), SNP (rsID), BP (base-pair position b38), EA_F (effect allele for fetal effect), NEA (non-effect allele), BETA_F_ADJ (beta of conditional fetal effect), SE_F_ADJ (standard error of conditional fetal effect), P_F_ADJ (p-value of conditional fetal effect), BETA_M_ADJ (beta of conditional maternal effect), SE_M_ADJ (standard error of conditional maternal effect), P_M_ADJ (p-value of conditional maternal effect), P_2DF (p-value of the two degree-of-freedom test), P_F_META (p-value of fetal 1-df meta-analysis), and P_M_META (p-value of maternal 1-df meta-analysis). For further details on sample sizes, analytical pipelines, and cohort-specific QC procedures, see Supplementary Materials.

Issued: 2025

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