Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP0212068]Researchers: Dr Wendy Jessup (Chief Investigator) , Katharina Gaus (Postdoctoral Fellow)
Brief description Cholesterol-dependent control of plasma membrane lipid rafts. Lipid rafts are recently discovered micro-domains in the plasma membrane that are highly enriched in cholesterol, giving these domains a unique lipid structure. Because of their distinct structure specific proteins partition into these domains so that lipid rafts act as message transduction centres in a variety of cell functions. It is hypothesised that cholesterol is the link between the distinct biophysical parameters of lipid rafts and their function. The aim of this proposal is to understand how cellular cholesterol levels contribute to raft structure and function, thus elevating cholesterol to a regulatory element for lipid raft and their function.
Funding Amount $231,000
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP0212068
- ARC : DP0212068