Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP0342760]Researchers: Joel Mackay (Chief Investigator) , Merlin Crossley (Chief Investigator) , Dr David Gell (Postdoctoral Fellow)
Brief description Characterization of erythroid differentiation related factor (EDRF): a novel a-globin binding protein. Hemoglobin, a four-subunit protein comprising two alpha and two beta polypeptide chains, is the essential oxygen transporter found in all mammals. Problems with the synthesis of hemoglobin can give rise to a range of common and serious human disorders, including thalassaemia and anemia. We have discovered a protein, EDRF, that appears to interact directly with alpha-globin (but not beta-globin) and to play a role in the regulation of hemoglobin production. We now seek to understand the nature of this interaction at a molecular level and mechanistic level.
Funding Amount $579,000
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP0342760
- ARC : DP0342760