Data

Bulk RNA-seq transcriptomic profiling of oral epithelium from HPV16 E7 transgenic and wild-type mice during 4NQO-induced oral carcinogenesis

The University of Queensland
Dr Janin Chandra (Aggregated by)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=info:doi10.48610/8e063d0&rft.title=Bulk RNA-seq transcriptomic profiling of oral epithelium from HPV16 E7 transgenic and wild-type mice during 4NQO-induced oral carcinogenesis&rft.identifier=RDM ID: 853a1c56-ad76-4bfa-86a8-cbedeb7da436&rft.publisher=The University of Queensland&rft.description=This dataset contains bulk RNA-sequencing data generated from oral tongue epithelium of wild-type (WT) and HPV16 E7 transgenic (K14E7) mice to investigate transcriptomic changes associated with persistent HPV16 E7 expression, biological sex, and 4-nitroquinoline-1-oxide (4NQO)-induced oral carcinogenesis. Male and female mice were included, with samples collected from untreated controls and following 4NQO exposure. The dataset comprises 32 biological samples representing genotype, treatment and sex groups (n = 4 per group). Oral epithelial tissue was collected and processed for RNA extraction and bulk RNA sequencing. Sequencing reads were demultiplexed at the sample level and adapter-trimmed using Cutadapt before downstream transcriptomic analysis. The accompanying metadata provides sample identifiers and the experimental variables required to interpret the sequencing files. These data support analyses of differential gene expression and pathway-level transcriptional changes associated with HPV16 E7 expression and carcinogen exposure in the oral epithelium.&rft.creator=Dr Janin Chandra&rft.date=2026&rft_rights= https://guides.library.uq.edu.au/deposit-your-data/license-reuse-data-agreement&rft_subject=eng&rft_subject=HPV16 E7&rft_subject=oral carcinogenesis&rft_subject=4-nitroquinoline 1-oxide&rft_subject=persistent HPV infection&rft_subject=sex differences&rft_subject=differential gene expression&rft_subject=gene expression profiling&rft_subject=carcinogen exposure&rft_subject=Immunology&rft_subject=BIOMEDICAL AND CLINICAL SCIENCES&rft_subject=Cancer cell biology&rft_subject=Oncology and carcinogenesis&rft.type=dataset&rft.language=English Access the data
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[email protected]
Faculty of Medicine

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This dataset contains bulk RNA-sequencing data generated from oral tongue epithelium of wild-type (WT) and HPV16 E7 transgenic (K14E7) mice to investigate transcriptomic changes associated with persistent HPV16 E7 expression, biological sex, and 4-nitroquinoline-1-oxide (4NQO)-induced oral carcinogenesis. Male and female mice were included, with samples collected from untreated controls and following 4NQO exposure. The dataset comprises 32 biological samples representing genotype, treatment and sex groups (n = 4 per group). Oral epithelial tissue was collected and processed for RNA extraction and bulk RNA sequencing. Sequencing reads were demultiplexed at the sample level and adapter-trimmed using Cutadapt before downstream transcriptomic analysis. The accompanying metadata provides sample identifiers and the experimental variables required to interpret the sequencing files. These data support analyses of differential gene expression and pathway-level transcriptional changes associated with HPV16 E7 expression and carcinogen exposure in the oral epithelium.

Issued: 2026

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Subjects
4-nitroquinoline 1-oxide | Biomedical and Clinical Sciences | Cancer Cell Biology | HPV16 E7 | Immunology | Oncology and Carcinogenesis | carcinogen exposure | differential gene expression | eng | gene expression profiling | oral carcinogenesis | persistent HPV infection | sex differences |

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Identifiers
ACN 633 798 857