Research Project
Full description Copper resistance is a key virulence trait of the uropathogen Proteus mirabilis. We have shown that P. mirabilis ScsC (PmScsC) contributes to this defense mechanism by enabling swarming in the presence of copper and found that PmScsC is a thioredoxin-like disulfide isomerase but, unlike other characterised proteins in this family, it is trimeric. This project focused on further understanding this unusual disulfide isomerase.