Research Grant
[Cite as https://purl.org/au-research/grants/arc/DP0343815]Researchers: Prof Philip Board (Chief Investigator) , The Australian National University (Managed by)
Brief description A genomic and phenomic investigation of a mitochondrial glutathione transferase. The aim of this study is to understand of the genomics, structure and function of glutathione transferase Kappa (GSTK), a novel GST found in mitochondria. The investigations will achieve several outcomes. (1)an understanding of the organisation of GSTK gene(s) in humans and mice; (2) determination of the role of GSTK in mitochondria, by investigating the phenotype of knockout mice; (3) determination of the crystal structure of human GSTK; (4) An understanding of GSTK's substrate specificity, reaction kinetics and structure/function relationships. Since GSTK is confined to mitochondria, and may not be related to other GSTs, we may also identify novel functions
Funding Amount $240,000
Funding Scheme Discovery Projects
- PURL : https://purl.org/au-research/grants/arc/DP0343815
- ARC : DP0343815