grant

Wrong parasite, wrong host? How Plasmodium falciparum erythrocyte membrane protein 1 expression and the host’s innate immune response combine to influence the inflammatory response to malaria in vitro and in vivo. Implications for severe malaria [ 2014 - 2016 ]

Also known as: How the malaria parasite and the host response to the parasite combine to increase risk of severe malaria

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1061993]

Researchers: Prof Stephen Rogerson (Principal investigator) ,  A/Pr Anthony Jaworowski

Brief description One factor that determines whether some children die of malaria is the type of protein that the parasite expresses on the red blood cell, to help it stick in blood vessels. Our new data suggests that some proteins stimulate excessive host immune response, possibly leading to severe malaria. People's immne response to malaria varies too, and we will discover whether severe malaria occurs when a dangerous parasite strain infects a susceptible host causing an excessive immune response, harming the child.

Funding Amount $AUD 707,821.70

Funding Scheme Project Grants

Notes Standard Project Grant

Click to explore relationships graph
Identifiers
Viewed: [[ro.stat.viewed]]
ACN 633 798 857