Data

WAMSI Node 5.2 - BioMolecular Diversity and Partnered Biodiscovery

Australian Ocean Data Network
Australian Institute of Marine Science (AIMS) (Associated with) Evans-Illidge, Libby, Dr (Point of contact) Harry Perkins Institute of Medical Research (Associated with) Leedman, Peter, Dr (Point of contact) Russell, Vikki (Point of contact)
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ctx_ver=Z39.88-2004&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Adc&rfr_id=info%3Asid%2FANDS&rft_id=https://catalogue.aodn.org.au:443/geonetwork/srv/api/records/0f44986b-2a52-4586-a613-c8de2c4102a4&rft.title=WAMSI Node 5.2 - BioMolecular Diversity and Partnered Biodiscovery&rft.identifier=0f44986b-2a52-4586-a613-c8de2c4102a4&rft.publisher=Australian Ocean Data Network&rft.description=This project is a three year research initiative focusing marine natural products (fine chemical) discovery and development research in key areas of Western Australian biomedicinal strength. The project builds on the recognition that the biodiversity of the States marine flora and fauna elicits significantly higher than expected hit rates in biomedicinal sectors especially The project offers a platform for additional collaborative venture into the future assuming legislative reform, sourcing the Biodiversity Library created in Project 1 for as wide a range of sectors as possible.Statement: The goal of this very interesting biodiscovery project was to perform proof-of-principle studies on a carefully selected group of marine samples in order to identify ones that have novel anticancer properties. This is an area of significant interest world-wide, as some marine-derived compounds are now entering early phase clinical trials in patients with cancer. So the precedent is a good one, and as WA has such unique and diverse marine organisms, the project holds great promise. However, the major issue in this node was the YEARS of DELAY in actually obtaining access to the samples, due to regulatory issues. Thanks to excellent work from the node leader Jason Froud, this approval was finally granted in late 2010 (over 2.5 years late). Fifty compounds isolated from up and down the WA coast were carefully selected by Prof Batershill and Dr Evans-Ilidge for potential anticancer activity based on an intimate knowledge of the marine organisms and Prof Battershill’s experience in the mining of other organisms with a collaborator at the NIH in the USA. These samples were provided by AIMS to Dr Jane Fromont from the WA Museum, who then delivered them to the Leedman laboratory in WAIMR (Western Australian Institute for Medical Research) as freeze dried preparations. They were then dissolved predominantly in methanol and used in cell proliferation assays to determine the IC50 of growth inhibition of two different human cancer cell lines (LNCaP, human prostate cancer; MCF-7, human breast cancer).&rft.creator=Anonymous&rft.date=2017&rft.coverage=westlimit=112.5; southlimit=-35.5; eastlimit=129; northlimit=-13.5&rft.coverage=westlimit=112.5; southlimit=-35.5; eastlimit=129; northlimit=-13.5&rft_subject=oceans&rft_subject=society&rft_subject=environment&rft_subject=health&rft_subject=Oceans | Marine Biology | Marine Invertebrates&rft_subject=MARINE HABITAT&rft_subject=EARTH SCIENCE&rft_subject=BIOSPHERE&rft_subject=AQUATIC ECOSYSTEMS&rft_subject=DISEASES/EPIDEMICS&rft_subject=HUMAN DIMENSIONS&rft_subject=PUBLIC HEALTH&rft_subject=Biodiscovery&rft.type=dataset&rft.language=English Access the data
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This project is a three year research initiative focusing marine natural products (fine chemical) discovery and development research in key areas of Western Australian biomedicinal strength. The project builds on the recognition that the biodiversity of the States marine flora and fauna elicits significantly higher than expected hit rates in biomedicinal sectors especially

The project offers a platform for additional collaborative venture into the future assuming legislative reform, sourcing the Biodiversity Library created in Project 1 for as wide a range of sectors as possible.

Lineage

Statement: The goal of this very interesting biodiscovery project was to perform proof-of-principle studies on a carefully selected group of marine samples in order to identify ones that have novel anticancer properties. This is an area of significant interest world-wide, as some marine-derived compounds are now entering early phase clinical trials in patients with cancer. So the precedent is a good one, and as WA has such unique and diverse marine organisms, the project holds great promise. However, the major issue in this node was the YEARS of DELAY in actually obtaining access to the samples, due to regulatory issues. Thanks to excellent work from the node leader Jason Froud, this approval was finally granted in late 2010 (over 2.5 years late). Fifty compounds isolated from up and down the WA coast were carefully selected by Prof Batershill and Dr Evans-Ilidge for potential anticancer activity based on an intimate knowledge of the marine organisms and Prof Battershill’s experience in the mining of other organisms with a collaborator at the NIH in the USA. These samples were provided by AIMS to Dr Jane Fromont from the WA Museum, who then delivered them to the Leedman laboratory in WAIMR (Western Australian Institute for Medical Research) as freeze dried preparations. They were then dissolved predominantly in methanol and used in cell proliferation assays to determine the IC50 of growth inhibition of two different human cancer cell lines (LNCaP, human prostate cancer; MCF-7, human breast cancer).

Created: 04 03 2009

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129,-13.5 129,-35.5 112.5,-35.5 112.5,-13.5 129,-13.5

120.75,-24.5

text: westlimit=112.5; southlimit=-35.5; eastlimit=129; northlimit=-13.5

Subjects
AQUATIC ECOSYSTEMS | BIOSPHERE | Biodiscovery | Diseases/epidemics | EARTH SCIENCE | HUMAN DIMENSIONS | Marine Habitat | Oceans | Marine Biology | Marine Invertebrates | PUBLIC HEALTH | environment | health | oceans | society |

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  • global : 0f44986b-2a52-4586-a613-c8de2c4102a4