grant

Viral-mediated modulation of BDNF expression in motor neurons to promote the recovery of hand/digits function in a rat model of spinal cord injury that impairs normal grasping action. [ 2013 - 2016 ]

Also known as: BDNF delivery to motor neurones in a rat model that impairs the grasping action

Funded by National Health and Medical Research Council
Managed by The University of New South Wales
Managed by University of New South Wales
Provided by   National Health and Medical Research Council

Research Grant

[Cite as http://purl.org/au-research/grants/nhmrc/1048764]

Researchers: Dr Renee Morris (Principal investigator) ,  A/Pr Matthias Klugmann ,  Prof Gary Housley ,  Prof Ian Whishaw

Brief description This project seeks to lure injured axons towards motor neurons, a process that is essential for the recovery of motor function. BDNF gradients will be created along the injured axons path. Axons will have to elongate to reach the first source of BDNF. They will need to elongate even more to get to the next source of BDNF, hence bringing them each time closer to their lost targets. This gene therapy scenario has the potential to bring gene therapy a step closer for human spinal cord injury.

Funding Amount $AUD 341,427.79

Funding Scheme Project Grants

Notes Standard Project Grant

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Subjects
Central Nervous System | Medical and Health Sciences | Neurosciences | axon regeneration | axonal reconnection | brain-derived neurotrophic factor (BDNF) | gene transfer | hand function | motor recovery | nerve excitability | rat | repair | spinal cord injury |
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