Vascular endothelial dysfunction in prenatal life predisposes to hypertension in adult life [ 2000 - 2002 ]

Research Grant

Researchers: Giuseppe Simonetta (Principal investigator)

Brief description An intact endothelial lining in the vascular system is important for the normal development and functioning of the cardiovascular system. Nitric oxide is a substance produced by the endothelium which acts on smooth muscle cells to cause relaxation. Recently, nitric oxide has been shown to play an important role in development of the cardiovascular system. This proposal aims to study the impact a dysfunctional endothelial lining, in particular a reduction in nitric oxide synthesis, has on development and control of the cardiovascular system. It is known that a reduction in nitric oxide synthesis, results in an increase in arterial blood pressure and an alteration in development of the smooth muscle cells of vessels. Studies in human populations have shown that individuals of low birth-weight, which is indicative of poor intrauterine development, are predisposed to developing cardiovascular diseases as adults. This study will investigate the impact reduced nitric oxide synthesis in the fetal period has on adult blood pressure. This study will investigate the mechanisms-factors which contribute to altered control and-or structure of heart and blood vessels in the fetus, newborn and adult after inhibition of the nitric oxide synthesis. The major outcomes of this proposal are that a disruption in nitric oxide synthesis during fetal life predisposes the individual to elevated blood pressure in adult life and an increased probability to becoming hypertensive if they are fatter or have a high salt intake.

Funding Amount $AUD 190,007.53

Funding Scheme NHMRC Project Grants

Notes New Investigator Grant