Vascular changes are a key contributor to and novel drug target for interferon-alpha induced neurological disease [ 1/1/2021 - 12/31/2024 ]

Research Grant

Brief description Type I interferons (IFN-Is) contribute to wide range of neurological diseases including ageing and neurodegeneration. At its extreme IFN-I-mediated neurodegeneration is known as 'interferonopathy'. The mechanisms of how IFN-Is drive disease are unclear, making causal treatment difficult. We have recently uncovered ground-breaking evidence that abnormal blood vessels are a key contributor to the disease. Here, we will investigate novel treatment targets for patients with interferonopathies.

Funding Amount $1,245,401

Funding Scheme Ideas Grants

Chief Investigator Dr Markus Hofer

Notes Ideas Grants