grant

Vaccine discovery for human mucosal pathogens: identifying novel vaccine antigens that are stably expressed during host interactions, using analysis of cell-contact and phasevarion mediated expression profiles [ 2013 - 2017 ]

Also known as: Investigating variable protein expression in human pathogens as a means to understand disease processes and to optimise the selection of vaccine antigens

Funded by National Health and Medical Research Council
Managed by Griffith University
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1045235]

Researchers: A/Pr Kate Seib (Principal investigator)

Brief description The control of several human pathogens depends on vaccine development due to antibiotic resistance and the devastating outcome of infection. This work aims to identify new vaccine targets for diseases including gonorrhoae, ear infections, meningitis and sepsis, based on proteins required for interaction with human cells. Proteins that are randomly switched on and off in these bacteria will also be studied to better understand disease and to rule out variably expressed genes from new vaccines.

Funding Amount $AUD 418,482.55

Funding Scheme Career Development Fellowships

Notes RD Wright Biomedical CDF

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Subjects
Medical and Health Sciences | Medical Microbiology | Medical Bacteriology | Moraxella catarrhalis | Neisseria gonorrhoeae | Neisseria meningitidis | antibody | host/pathogen interaction | microbial pathogenesis | vaccine candidate molecules | virulence factors |
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ACN 633 798 857