Research Grant
[Cite as https://purl.org/au-research/grants/nhmrc/404065]Researchers: Prof Jiake Xu (Principal investigator) , Prof Minghao Zheng
Brief description Overproduction and excessive activity of osteoclasts underlines many lytic bone disorders such as osteoporosis, Paget's disease and tumor-induced bone loss. The vacuolar proton pump (V-ATPase) located on the plasma membrane of the osteoclast is critical for osteoclastic bone resorption and, therefore represents a potential molecular target for the discovery of novel bone anti-resorptive agents. The proposed project addresses the fundamental role of the V-ATPase in osteoclast differentiation, acidification and bone resorption. Understanding the molecular and cellular mechanisms by which V-ATPases regulate osteoclast function and bone resorption will facilitate the development of novel and selective inhibitors for the treatment of lytic bone disorders
Funding Amount $AUD 531,264.67
Funding Scheme NHMRC Project Grants
Notes Standard Project Grant
- nhmrc : 404065
- PURL : https://purl.org/au-research/grants/nhmrc/404065
