The utility of genomics and functional imaging to predict Irinotecan and Sunitinib pharmacokinetics and pharmacodynamics [ 2010 - 2015 ]

Research Grant

Researchers: A/Pr Michael Michael (Principal investigator) ,  A/Pr Guy Toner ,  Dr Carleen Cullinane ,  Prof Grant Mcarthur ,  Prof Rodney Hicks

Brief description Cancer patients have large differences in the way their liver breaks down anticancer drugs, leading to a poor tumor response or severe side effects. This project will be with 2 cancer drugs which can cause severe side effects. Patients will have special liver Xrays to check their liver function and have blood taken to look at DNA or genes important in drug breakdown and action. These genes and imaging may help identify patients at risk of severe toxicity or poor response and optimise drug use.

Funding Amount $AUD 815,733.26

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant