Using Nkx2-5 knock-in mouse models to understand complex cardiac diseases [ 2014 - 2016 ]

Research Grant

Researchers: Dr Mauro Costa (Principal investigator) ,  Dr Mirana Ramialison (Principal investigator) ,  Prof Nadia Rosenthal (Principal investigator)

Brief description The most common cause of postnatal mortality is heart defects associated with mutation in transcriptional factors, of which NKX2-5 is the master gene. NKX2-5 is also involved in cardiac dysfunction in adults. We developed a unique mouse genetic approach that mimics human disease to study the mechanism behind this gene function. Our work paves the way to more efficient forecast, counseling and treatment strategies, reducing the socio-economic burden of congenital heart disease our community.

Funding Amount $AUD 611,340.37

Funding Scheme Project Grants

Notes Standard Project Grant