Using mouse models to decipher the function of caspase-2 in limiting aneuploidy tolerance and cancer [ 2018 - 2020 ]

Research Grant

Researchers: Dr Loretta Dorstyn (Principal investigator) ,  Prof Sharad Kumar ,  Prof Vinay Tergaonkar

Brief description Aneuploidy or abnormal chromosome number is a feature of cancer cells. The extent of aneuploidy is often predictive of prognosis and the effectiveness of cancer treatment. We discovered that a tumour suppressing protein, caspase-2, is important for deleting aneuploid cells that may otherwise become cancerous. In this project we will use cancer models to decipher how caspase-2 safeguards against aneuploidy and cancer to better understand how cancer cells can survive and be targeted for treatment.

Funding Amount $AUD 883,358.28

Funding Scheme Project Grants

Notes Standard Project Grant