grant

The use of soluble antagonists of EphA4 in spinal cord injuries [ 2008 - 2010 ]

Also known as: Is recovery from spinal cord injuries improved if we neutralise EphA4

Funded by National Health and Medical Research Council
Managed by The University of Queensland
Managed by University of Queensland
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/511212]

Researchers: Prof Perry Bartlett (Principal investigator) ,  A/Pr Ann Turnley ,  E/Pr Andrew Boyd ,  Prof Dimitar Nikolov

Brief description Permanent and limited recovery of function following spinal cord injury is a direct result of the lack of nerve regrowth through the injury. Our preliminary data suggest that antagonising the effects of EphA4, a protein involved in brain development, leads to substantial functional recovery simultaneous with nerve regrowth. In addition to designing new, more effective blockers of EphA4, we will study the signalling pathways that EphA4 activates to inhibit nerve regrowth.

Funding Amount $AUD 622,361.35

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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Subjects
Biomedical and Clinical Sciences | Eph-ephrin signalling | Medical Infection Agents (Incl. Prions) | Medical Microbiology | motor recovery | movement dysfunction | nerve damage | nerve regeneration | nerve repair | neural regeneration | neurite outgrowth | spinal cord injury |
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ACN 633 798 857