Unveiling the origin of Munc18-1 and alpha-synuclein co-aggregation at nanoscale [ 2018 - ]

Research Grant

Researchers: Prof Frederic Meunier (Principal investigator) ,  A/Pr Brett Collins ,  A/Pr Bruno van Swinderen

Brief description Our recent work on Munc18-1 mutations leading to a severe form of human early infantile epileptic encephalopathy (EIEE) led us to uncover a critical role for Munc18-1 in controlling the formation of toxic protein aggregates containing α-Synuclein. Targeting the Munc18-1 α-Synuclein interaction may have therapeutic values not only for EIEE but also for other neurological diseases characterised by protein aggregations.

Funding Amount $620,005.00

Funding Scheme Project Grants

Notes Standard Project Grant