Unravelling NET confusion in Vasculitis [ 1/1/2021 - 12/31/2024 ]

Research Grant

Brief description Current therapy for AAV has major toxicities and 30% of Patients are dead or on dialysis within 3 years. This proposal aims to study a unique form of cell death termed Neutrophil extracellular traps (NETs) that initiates and perpetuates inflammation in this disease. We will use an animal model of the disease that mirrors human disease. We will inhibit crucial molecules in NET production to attenuate disease. This will provide proof of concept evidence to promote clinical trials in patients.

Funding Amount $1,044,052

Funding Scheme Ideas Grants

Chief Investigator Dr Kim Maree O'Sullivan

Notes Ideas Grants