grant

Unravelling the mechanism of MHC class-I associated drug hypersensitivities [ 2009 - 2011 ]

Also known as: The basis of immune-mediated drug reactions

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/566730]

Researchers: Prof James Mccluskey (Principal investigator) ,  A/Pr Mandvi Bharadwaj A/Pr Nicholas Williamson

Brief description Some drugs cause adverse reactions that are life threatening. We think these reactions are mediated by killer T cells as they are genetically controlled by immune response genes that normally guide immunity to microbes. We will study immune reactions to the drug abacavir, used to treat HIV (AIDS); allopurinol used to prevent gout and carbamazepine, used to treat epilepsy. The study may also help devise better treatments for patients who experience severe forms of these reactions.

Funding Amount $AUD 566,308.79

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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