Unravelling how exosomes induce and propagate tau pathology [ 2019 - ]

Research Grant

Brief description We have established that brains from mice with tau pathology produce tau seeds 'encapsulated' within extracellular vesicles known as exosomes. Furthermore, exosomes containing tau seeds can induce tau aggregation in recipient cells, and exosomes spread from neuron to neuron by hijacking endosomes. We aim to determine how exosomal tau seeds escape endosomes, and whether controlling the exosome production or traffic can halt or reduce tau pathology.

Funding Amount $827,521.00

Funding Scheme Project Grants

Notes Standard Project Grant