Unraveling fibrosis by pharmacological targeting of the G protein-coupled receptor, RXFP1 [ 2017 - 2019 ]

Research Grant

Researchers: Dr Mohammed Hossain (Principal investigator) ,  A/Pr Chrishan Samuel ,  Dr Karl Johan Rosengren ,  Dr Martina Kocan ,  Dr Song Yao
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Brief description Peptides, with their high specificity and low toxicity profiles, are highly attractive alternatives to small molecule drugs. H2 relaxin, a peptide hormone, has a strong potential for treating fibrosis. However, the large size of H2 relaxin makes it difficult and expensive to manufacture. Once administered to patients, it is also quickly degraded. We have developed a small anti-fibrotic relaxin peptide, and propose to understand its mechanism of action and improve its therapeutic indices.

Funding Amount $AUD 816,647.85

Funding Scheme Project Grants

Notes Standard Project Grant