grant

Unique isoform-specific regulation of cardiac ryanodine receptors by calcium store proteins [ 2010 - 2013 ]

Also known as: Calcium store regulation in the heart

Funded by National Health and Medical Research Council
Managed by Australian National University
Managed by The Australian National University
Provided by   National Health and Medical Research Council

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/585474]

Researchers: E/Pr Angela Dulhunty (Principal investigator) ,  A/Pr Nicole Beard ,  Prof Sandor Gyorke ,  The Australian National University (Managed by)

Brief description The importance of proteins that regulate calcium stores of heart muscle is graphically illustrated by massive changes in cell structure and function, which lead to ventricular fibrillation and fatality when the proteins are disrupted. We recently made the remarkable discovery that the proteins have a unique action in the heart which enhances cardiac contraction. We will discover the interaction sites between the proteins and will define novel therapeutic targets for heart failure.

Funding Amount $AUD 421,160.97

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

Click to explore relationships graph
Help

Related Organisations

Related People

Subjects
Cardiorespiratory Medicine and Haematology | Cardiac calsequestrin calcium binding proteins | Cardiac muscle function | Cardiac ryanodine receptor calcium release channels | Cardiac triadin and junctin | Cardiology (Incl. Cardiovascular Diseases) | Medical and Health Sciences | Regulation of calcium stores in the heart | heart disease | heart failure | polymorphic ventricular tachycardia | sudden cardiac death | ventricular fibrillation |
Identifiers
Viewed: [[ro.stat.viewed]]
Saved to MyRDA Save to MyRDA