Unified model for group A streptococcal invasive disease initiation. [ 2007 - 2009 ]

Also known as: Understanding group A streptococcal invasive disease.

Research Grant

[Cite as]

Researchers: Prof Mark Walker (Principal investigator) ,  Dr Malak Kotb Prof Gurshuran Chhatwal Prof Victor Nizet

Brief description Streptococcus pyogenes (group A streptococcus; GAS) is a bacterium that causes human skin and throat infections as well as highly invasive diseases including necrotising fasciitis and streptococcal toxic shock-like syndrome. We have recently discovered the trigger mechanism for GAS invasive disease. We hypothesise that the initial host response at the site of infection selects for a GAS invasive phenotype. We propose to examine the chain of events which result in tissue invasion in order to understand these disease processes and allow the development of future therapeutic interventions.

Funding Amount $AUD 605,221.74

Funding Scheme NHMRC Project Grants

Notes Standard Project Grant

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