grant

The unfolded protein response in inherited musculoskeletal disease - mechanisms and therapeutic strategies [ 2013 - 2015 ]

Research Grant

[Cite as https://purl.org/au-research/grants/nhmrc/1049863]

Researchers: Prof John Bateman (Principal investigator)

Brief description In genetic diseases, gene mutations commonly cause proteins to fold abnormally. This can cause cell stress resulting in cell death. Our studies will determine the role of cell stress in a clinically important group of debilitating inherited bone and cartilage diseases caused by collagen mutations. Our studies will explore the mechanisms of how this stress causes the disease, but importantly will translate these findings by testing a new therapeutic strategy strengthen bones in brittle bone disease.

Funding Amount $AUD 643,607.29

Funding Scheme Project Grants

Notes Standard Project Grant

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Identifiers
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ACN 633 798 857